$regex needs to be string compared to the $regex from the previous pass of the loop, so I don't see the gain unless you use a regex instead of a regex pattern. 

my @strings = qw(ABC DEF GHI JKL);
my $regex = join '|', map "\Q$_\E", @strings;
$regex = qr/$regex/i;

foreach my $file (@files) {
  my $data = slurp $file;
  if ($data =~ $regex) {
    print " Match\n";
  }
}

[download]

There may be a gain from not using /i. 

my @strings = qw(ABC DEF GHI JKL);
my $regex = lc join '|', map "\Q$_\E", @strings;
$regex = qr/$regex/;

foreach my $file (@files) {
  my $data = slurp $file;
  if (lc($data) =~ $regex) {
    print " Match\n";
  }
}

[download]

It seems to disable 5.10's trie optimisation, for starters. 

$ perl -Mre=debug -e'qr/foo|bar|baz|boo/'
Compiling REx "foo|bar|baz|boo"
Final program:
   1: TRIEC-EXACT[bf] (13)
      <foo>
      <bar>
      <baz>
      <boo>
  13: END (0)
stclass AHOCORASICKC-EXACT[bf] minlen 3
Freeing REx: "foo|bar|baz|boo"

$ perl -Mre=debug -e'qr/foo|bar|baz|boo/i'
Compiling REx "foo|bar|baz|boo"
Final program:
   1: BRANCH (4)
   2:   EXACTF <foo> (13)
   4: BRANCH (7)
   5:   EXACTF <bar> (13)
   7: BRANCH (10)
   8:   EXACTF <baz> (13)
  10: BRANCH (FAIL)
  11:   EXACTF <boo> (13)
  13: END (0)
minlen 3
Freeing REx: "foo|bar|baz|boo"

[download]

In reply to Re^2: Better way to search array for elements in other array? by ikegami
in thread Better way to search array for elements in other array? by echo5

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