I would assume Inline::CPP, at least for the direction of calling C++ from Perl. For calling Perl code from C++, you will have to embed a Perl interpreter (see perlembed), or talk to Perl over a socket connection.

In reply to Re: boost.python C++ interoperability equivalent in Perl? by Corion
in thread boost.python C++ interoperability equivalent in Perl? by hermida

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