LOCUS       NP_644805                770 aa            linear   PRI 06
+-FEB-2011
DEFINITION  signal transducer and activator of transcription 3 isoform
+ 1 [Homo
            sapiens].
ACCESSION   NP_644805
VERSION     NP_644805.1  GI:21618340
DBSOURCE    REFSEQ: accession NM_139276.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Eutele
+ostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhin
+i;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 770)
  AUTHORS   Davidson,S.I., Liu,Y., Danoy,P.A., Wu,X., Thomas,G.P., Jia
+ng,L.,
            Sun,L., Wang,N., Han,J., Han,H., Visscher,P.M., Brown,M.A.
+ and
            Xu,H.
  CONSRTM   Australo-Anglo-American Spondyloarthritis Consortium
  TITLE     Association of STAT3 and TNFRSF1A with ankylosing spondyli
+tis in
            Han Chinese
  JOURNAL   Ann. Rheum. Dis. 70 (2), 289-292 (2011)
   PUBMED   21068102
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
REFERENCE   2  (residues 1 to 770)
  AUTHORS   Budarf,M.L., Goyette,P., Boucher,G., Lian,J., Graham,R.R.,
            Claudio,J.O., Hudson,T., Gladman,D., Clarke,A.E., Pope,J.E
+.,
            Peschken,C., Smith,C.D., Hanly,J., Rich,E., Boire,G., Barr
+,S.G.,
            Zummer,M., Fortin,P.R., Wither,J. and Rioux,J.D.
  CONSRTM   GenES Investigators
  TITLE     A targeted association study in systemic lupus erythematos
+us
            identifies multiple susceptibility alleles
  JOURNAL   Genes Immun. 12 (1), 51-58 (2011)
   PUBMED   20962850
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
REFERENCE   3  (residues 1 to 770)
  AUTHORS   Hosur,V. and Loring,R.H.
  TITLE     alpha4beta2 nicotinic receptors partially mediate anti-inf
+lammatory
            effects through Janus kinase 2-signal transducer and activ
+ator of
            transcription 3 but not calcium or cAMP signaling
  JOURNAL   Mol. Pharmacol. 79 (1), 167-174 (2011)
   PUBMED   20943775
  REMARK    GeneRIF: A role was determined for signal transducer and a
+ctivator
            of transcription 3 and Janus kinase-2 transduction in alph
+a4beta2
            nicotinic receptor-mediated anti-inflammatory effects.
REFERENCE   4  (residues 1 to 770)
  AUTHORS   Laukens,D., Georges,M., Libioulle,C., Sandor,C., Mni,M., V
+ander
            Cruyssen,B., Peeters,H., Elewaut,D. and De Vos,M.
  TITLE     Evidence for significant overlap between common risk varia
+nts for
            Crohn's disease and ankylosing spondylitis
  JOURNAL   PLoS ONE 5 (11), E13795 (2010)
   PUBMED   21072187
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 770)
  AUTHORS   Shukla,S., Shishodia,G., Mahata,S., Hedau,S., Pandey,A.,
            Bhambhani,S., Batra,S., Basir,S.F., Das,B.C. and Bharti,A.
+C.
  TITLE     Aberrant expression and constitutive activation of STAT3 i
+n
            cervical carcinogenesis: implications in high-risk human
            papillomavirus infection
  JOURNAL   Mol. Cancer 9, 282 (2010)
   PUBMED   20977777
  REMARK    GeneRIF: Data show that in the presence of HPV16, STAT3 is
            aberrantly-expressed and constitutively-activated in cervi
+cal
            cancer which increases as the lesion progresses thus indic
+ating its
            potential role in progression of HPV16-mediated cervical
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 770)
  AUTHORS   Boulton,T.G., Zhong,Z., Wen,Z., Darnell,J.E. Jr., Stahl,N.
+ and
            Yancopoulos,G.D.
  TITLE     STAT3 activation by cytokines utilizing gp130 and related
            transducers involves a secondary modification requiring an
            H7-sensitive kinase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (15), 6915-6919 (1995)
   PUBMED   7624343
REFERENCE   7  (residues 1 to 770)
  AUTHORS   Lin,J.X., Migone,T.S., Tsang,M., Friedmann,M., Weatherbee,
+J.A.,
            Zhou,L., Yamauchi,A., Bloom,E.T., Mietz,J., John,S. et al.
  TITLE     The role of shared receptor motifs and common Stat protein
+s in the
            generation of cytokine pleiotropy and redundancy by IL-2, 
+IL-4,
            IL-7, IL-13, and IL-15
  JOURNAL   Immunity 2 (4), 331-339 (1995)
   PUBMED   7719938
REFERENCE   8  (residues 1 to 770)
  AUTHORS   Zhang,X., Blenis,J., Li,H.C., Schindler,C. and Chen-Kiang,
+S.
  TITLE     Requirement of serine phosphorylation for formation of
            STAT-promoter complexes
  JOURNAL   Science 267 (5206), 1990-1994 (1995)
   PUBMED   7701321
REFERENCE   9  (residues 1 to 770)
  AUTHORS   Akira,S., Nishio,Y., Inoue,M., Wang,X.J., Wei,S., Matsusak
+a,T.,
            Yoshida,K., Sudo,T., Naruto,M. and Kishimoto,T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene fac
+tor 3
            p91-related transcription factor involved in the gp130-med
+iated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
REFERENCE   10 (residues 1 to 770)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H.
+ and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Ba
+rr virus
            shuttle system
  JOURNAL   Mol. Cell. Biol. 7 (1), 379-387 (1987)
   PUBMED   3031469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staf
+f. The
            reference sequence was derived from BI461226.1, BC014482.1
+,
            AK092965.1, CB216860.1, BC008044.2, CF454565.1 and AI63189
+6.1.
            This sequence is a reference standard in the RefSeqGene pr
+oject.
            On May 7, 2004 this sequence version replaced gi:16596688.
            
            Summary: The protein encoded by this gene is a member of t
+he STAT
            protein family. In response to cytokines and growth factor
+s, STAT
            family members are phosphorylated by the receptor associat
+ed
            kinases, and then form homo- or heterodimers that transloc
+ate to
            the cell nucleus where they act as transcription activator
+s. This
            protein is activated through phosphorylation in response t
+o various
            cytokines and growth factors including IFNs, EGF, IL5, IL6
+, HGF,
            LIF and BMP2. This protein mediates the expression of a va
+riety of
            genes in response to cell stimuli, and thus plays a key ro
+le in
            many cellular processes such as cell growth and apoptosis.
+ The
            small GTPase Rac1 has been shown to bind and regulate the 
+activity
            of this protein. PIAS3 protein is a specific inhibitor of 
+this
            protein. Three alternatively spliced transcript variants e
+ncoding
            distinct isoforms have been described. [provided by RefSeq
+].
            
            Transcript Variant: This variant (1) represents the longes
+t
            transcript, and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of
+ the
            publications that are available for this gene. Please see 
+the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     Protein         1..770
                     /product="signal transducer and activator of tran
+scription
                     3 isoform 1"
                     /note="acute-phase response factor; DNA-binding p
+rotein
                     APRF"
                     /calculated_mol_wt=87937
     Region          150..162
                     /region_name="Essential for nuclear import"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P407
+63.2)"
     Site            539
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     Site            691
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/S
+wiss-Prot
                     (P40763.2)"
     Site            705
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     Site            714
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     Site            727
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphoserine, by NLK; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     CDS             1..770
                     /gene="STAT3"
                     /gene_synonym="APRF; FLJ20882; HIES; MGC16063"
                     /coded_by="NM_139276.2:241..2553"
                     /note="isoform 1 is encoded by transcript variant
+ 1"
                     /db_xref="CCDS:CCDS32656.1"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:11364"
                     /db_xref="HPRD:00026"
                     /db_xref="MIM:102582"
ORIGIN      
        1 maqwnqlqql dtryleqlhq lysdsfpmel rqflapwies qdwayaaske shatl
+vfhnl
       61 lgeidqqysr flqesnvlyq hnlrrikqfl qsrylekpme iarivarclw eesrl
+lqtaa
      121 taaqqggqan hptaavvtek qqmleqhlqd vrkrvqdleq kmkvvenlqd dfdfn
+yktlk
      181 sqgdmqdlng nnqsvtrqkm qqleqmltal dqmrrsivse lagllsamey vqktl
+tdeel
      241 adwkrrqqia ciggppnicl drlenwitsl aesqlqtrqq ikkleelqqk vsykg
+dpivq
      301 hrpmleeriv elfrnlmksa fvverqpcmp mhpdrplvik tgvqfttkvr llvkf
+pelny
      361 qlkikvcidk dsgdvaalrg srkfnilgtn tkvmnmeesn ngslsaefkh ltlre
+qrcgn
      421 ggrancdasl ivteelhlit fetevyhqgl kidlethslp vvvisnicqm pnawa
+silwy
      481 nmltnnpknv nfftkppigt wdqvaevlsw qfssttkrgl sieqlttlae kllgp
+gvnys
      541 gcqitwakfc kenmagkgfs fwvwldniid lvkkyilalw negyimgfis kerer
+ailst
      601 kppgtfllrf sesskeggvt ftwvekdisg ktqiqsvepy tkqqlnnmsf aeiim
+gykim
      661 datnilvspl vylypdipke eafgkycrpe sqehpeadpg saapylktkf icvtp
+ttcsn
      721 tidlpmsprt ldslmqfgnn gegaepsagg qfesltfdme ltsecatspm
//

LOCUS       NP_003141                769 aa            linear   PRI 06
+-FEB-2011
DEFINITION  signal transducer and activator of transcription 3 isoform
+ 2 [Homo
            sapiens].
ACCESSION   NP_003141 NP_444275
VERSION     NP_003141.2  GI:21618338
DBSOURCE    REFSEQ: accession NM_003150.3
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Eutele
+ostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhin
+i;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 769)
  AUTHORS   Davidson,S.I., Liu,Y., Danoy,P.A., Wu,X., Thomas,G.P., Jia
+ng,L.,
            Sun,L., Wang,N., Han,J., Han,H., Visscher,P.M., Brown,M.A.
+ and
            Xu,H.
  CONSRTM   Australo-Anglo-American Spondyloarthritis Consortium
  TITLE     Association of STAT3 and TNFRSF1A with ankylosing spondyli
+tis in
            Han Chinese
  JOURNAL   Ann. Rheum. Dis. 70 (2), 289-292 (2011)
   PUBMED   21068102
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
REFERENCE   2  (residues 1 to 769)
  AUTHORS   Budarf,M.L., Goyette,P., Boucher,G., Lian,J., Graham,R.R.,
            Claudio,J.O., Hudson,T., Gladman,D., Clarke,A.E., Pope,J.E
+.,
            Peschken,C., Smith,C.D., Hanly,J., Rich,E., Boire,G., Barr
+,S.G.,
            Zummer,M., Fortin,P.R., Wither,J. and Rioux,J.D.
  CONSRTM   GenES Investigators
  TITLE     A targeted association study in systemic lupus erythematos
+us
            identifies multiple susceptibility alleles
  JOURNAL   Genes Immun. 12 (1), 51-58 (2011)
   PUBMED   20962850
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
REFERENCE   3  (residues 1 to 769)
  AUTHORS   Hosur,V. and Loring,R.H.
  TITLE     alpha4beta2 nicotinic receptors partially mediate anti-inf
+lammatory
            effects through Janus kinase 2-signal transducer and activ
+ator of
            transcription 3 but not calcium or cAMP signaling
  JOURNAL   Mol. Pharmacol. 79 (1), 167-174 (2011)
   PUBMED   20943775
  REMARK    GeneRIF: A role was determined for signal transducer and a
+ctivator
            of transcription 3 and Janus kinase-2 transduction in alph
+a4beta2
            nicotinic receptor-mediated anti-inflammatory effects.
REFERENCE   4  (residues 1 to 769)
  AUTHORS   Laukens,D., Georges,M., Libioulle,C., Sandor,C., Mni,M., V
+ander
            Cruyssen,B., Peeters,H., Elewaut,D. and De Vos,M.
  TITLE     Evidence for significant overlap between common risk varia
+nts for
            Crohn's disease and ankylosing spondylitis
  JOURNAL   PLoS ONE 5 (11), E13795 (2010)
   PUBMED   21072187
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 769)
  AUTHORS   Shukla,S., Shishodia,G., Mahata,S., Hedau,S., Pandey,A.,
            Bhambhani,S., Batra,S., Basir,S.F., Das,B.C. and Bharti,A.
+C.
  TITLE     Aberrant expression and constitutive activation of STAT3 i
+n
            cervical carcinogenesis: implications in high-risk human
            papillomavirus infection
  JOURNAL   Mol. Cancer 9, 282 (2010)
   PUBMED   20977777
  REMARK    GeneRIF: Data show that in the presence of HPV16, STAT3 is
            aberrantly-expressed and constitutively-activated in cervi
+cal
            cancer which increases as the lesion progresses thus indic
+ating its
            potential role in progression of HPV16-mediated cervical
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 769)
  AUTHORS   Boulton,T.G., Zhong,Z., Wen,Z., Darnell,J.E. Jr., Stahl,N.
+ and
            Yancopoulos,G.D.
  TITLE     STAT3 activation by cytokines utilizing gp130 and related
            transducers involves a secondary modification requiring an
            H7-sensitive kinase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (15), 6915-6919 (1995)
   PUBMED   7624343
REFERENCE   7  (residues 1 to 769)
  AUTHORS   Lin,J.X., Migone,T.S., Tsang,M., Friedmann,M., Weatherbee,
+J.A.,
            Zhou,L., Yamauchi,A., Bloom,E.T., Mietz,J., John,S. et al.
  TITLE     The role of shared receptor motifs and common Stat protein
+s in the
            generation of cytokine pleiotropy and redundancy by IL-2, 
+IL-4,
            IL-7, IL-13, and IL-15
  JOURNAL   Immunity 2 (4), 331-339 (1995)
   PUBMED   7719938
REFERENCE   8  (residues 1 to 769)
  AUTHORS   Zhang,X., Blenis,J., Li,H.C., Schindler,C. and Chen-Kiang,
+S.
  TITLE     Requirement of serine phosphorylation for formation of
            STAT-promoter complexes
  JOURNAL   Science 267 (5206), 1990-1994 (1995)
   PUBMED   7701321
REFERENCE   9  (residues 1 to 769)
  AUTHORS   Akira,S., Nishio,Y., Inoue,M., Wang,X.J., Wei,S., Matsusak
+a,T.,
            Yoshida,K., Sudo,T., Naruto,M. and Kishimoto,T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene fac
+tor 3
            p91-related transcription factor involved in the gp130-med
+iated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
REFERENCE   10 (residues 1 to 769)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H.
+ and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Ba
+rr virus
            shuttle system
  JOURNAL   Mol. Cell. Biol. 7 (1), 379-387 (1987)
   PUBMED   3031469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staf
+f. The
            reference sequence was derived from BI461226.1, BC000627.2
+,
            AK092965.1, CB216860.1, BC008044.2, CF454565.1 and AI63189
+6.1.
            On Jun 27, 2002 this sequence version replaced gi:4507253.
            
            Summary: The protein encoded by this gene is a member of t
+he STAT
            protein family. In response to cytokines and growth factor
+s, STAT
            family members are phosphorylated by the receptor associat
+ed
            kinases, and then form homo- or heterodimers that transloc
+ate to
            the cell nucleus where they act as transcription activator
+s. This
            protein is activated through phosphorylation in response t
+o various
            cytokines and growth factors including IFNs, EGF, IL5, IL6
+, HGF,
            LIF and BMP2. This protein mediates the expression of a va
+riety of
            genes in response to cell stimuli, and thus plays a key ro
+le in
            many cellular processes such as cell growth and apoptosis.
+ The
            small GTPase Rac1 has been shown to bind and regulate the 
+activity
            of this protein. PIAS3 protein is a specific inhibitor of 
+this
            protein. Three alternatively spliced transcript variants e
+ncoding
            distinct isoforms have been described. [provided by RefSeq
+].
            
            Transcript Variant: This variant (2) lacks a segment in th
+e 5' UTR
            and 3 nt within the CDS, as compared to variant 1. The res
+ulting
            isoform (2) lacks an amino acid compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of
+ the
            publications that are available for this gene. Please see 
+the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     Protein         1..769
                     /product="signal transducer and activator of tran
+scription
                     3 isoform 2"
                     /note="acute-phase response factor; DNA-binding p
+rotein
                     APRF"
                     /calculated_mol_wt=87850
     Region          150..162
                     /region_name="Essential for nuclear import"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P407
+63.2)"
     Site            539
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     Site            691
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/S
+wiss-Prot
                     (P40763.2)"
     Site            704
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     Site            713
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     Site            726
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Phosphoserine, by NLK; propagated from
                     UniProtKB/Swiss-Prot (P40763.2)"
     CDS             1..769
                     /gene="STAT3"
                     /gene_synonym="APRF; FLJ20882; HIES; MGC16063"
                     /coded_by="NM_003150.3:219..2528"
                     /note="isoform 2 is encoded by transcript variant
+ 2"
                     /db_xref="CCDS:CCDS32657.1"
                     /db_xref="GeneID:6774"
                     /db_xref="HGNC:11364"
                     /db_xref="HPRD:00026"
                     /db_xref="MIM:102582"
ORIGIN      
        1 maqwnqlqql dtryleqlhq lysdsfpmel rqflapwies qdwayaaske shatl
+vfhnl
       61 lgeidqqysr flqesnvlyq hnlrrikqfl qsrylekpme iarivarclw eesrl
+lqtaa
      121 taaqqggqan hptaavvtek qqmleqhlqd vrkrvqdleq kmkvvenlqd dfdfn
+yktlk
      181 sqgdmqdlng nnqsvtrqkm qqleqmltal dqmrrsivse lagllsamey vqktl
+tdeel
      241 adwkrrqqia ciggppnicl drlenwitsl aesqlqtrqq ikkleelqqk vsykg
+dpivq
      301 hrpmleeriv elfrnlmksa fvverqpcmp mhpdrplvik tgvqfttkvr llvkf
+pelny
      361 qlkikvcidk dsgdvaalrg srkfnilgtn tkvmnmeesn ngslsaefkh ltlre
+qrcgn
      421 ggrancdasl ivteelhlit fetevyhqgl kidlethslp vvvisnicqm pnawa
+silwy
      481 nmltnnpknv nfftkppigt wdqvaevlsw qfssttkrgl sieqlttlae kllgp
+gvnys
      541 gcqitwakfc kenmagkgfs fwvwldniid lvkkyilalw negyimgfis kerer
+ailst
      601 kppgtfllrf sesskeggvt ftwvekdisg ktqiqsvepy tkqqlnnmsf aeiim
+gykim
      661 datnilvspl vylypdipke eafgkycrpe sqehpeadpg aapylktkfi cvtpt
+tcsnt
      721 idlpmsprtl dslmqfgnng egaepsaggq fesltfdmel tsecatspm
//

LOCUS       NP_612815                233 aa            linear   PRI 10
+-FEB-2011
DEFINITION  bcl-2-like protein 1 isoform 1 [Homo sapiens].
ACCESSION   NP_612815
VERSION     NP_612815.1  GI:20336335
DBSOURCE    REFSEQ: accession NM_138578.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Eutele
+ostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhin
+i;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 233)
  AUTHORS   Mayeenuddin,L.H., Yu,Y., Kang,Z., Helman,L.J. and Cao,L.
  TITLE     Insulin-like growth factor 1 receptor antibody induces
            rhabdomyosarcoma cell death via a process involving AKT an
+d
            Bcl-x(L)
  JOURNAL   Oncogene 29 (48), 6367-6377 (2010)
   PUBMED   20818434
  REMARK    GeneRIF: Rhabdomyosarcoma pathogenesis involves increased 
+IGF1R
            expression that enhances AKT and Bcl-x(L)-mediated cell su
+rvival.
REFERENCE   2  (residues 1 to 233)
  AUTHORS   Kelly,J.L., Novak,A.J., Fredericksen,Z.S., Liebow,M., Anse
+ll,S.M.,
            Dogan,A., Wang,A.H., Witzig,T.E., Call,T.G., Kay,N.E.,
            Habermann,T.M., Slager,S.L. and Cerhan,J.R.
  TITLE     Germline variation in apoptosis pathway genes and risk of
            non-Hodgkin's lymphoma
  JOURNAL   Cancer Epidemiol. Biomarkers Prev. 19 (11), 2847-2858 (201
+0)
   PUBMED   20855536
  REMARK    GeneRIF: Observational study of gene-disease association. 
+(HuGE
            Navigator)
REFERENCE   3  (residues 1 to 233)
  AUTHORS   Gonzalez,M.S., De Brasi,C.D., Bianchini,M., Gargallo,P.,
            Moiraghi,B., Bengio,R. and Larripa,I.B.
  TITLE     BAX/BCL-XL gene expression ratio inversely correlates with
+ disease
            progression in chronic myeloid leukemia
  JOURNAL   Blood Cells Mol. Dis. 45 (3), 192-196 (2010)
   PUBMED   20728382
  REMARK    GeneRIF: BAX/BCL-XL expression ratio may be a sensitive mo
+nitor of
            disease progression and an early predictor of TKI therapy
            responsiveness in CML patients.
REFERENCE   4  (residues 1 to 233)
  AUTHORS   Boise,L.H., Minn,A.J., Noel,P.J., June,C.H., Accavitti,M.A
+.,
            Lindsten,T. and Thompson,C.B.
  TITLE     CD28 costimulation can promote T cell survival by enhancin
+g the
            expression of Bcl-xL. Immunity. 1995. 3: 87-98
  JOURNAL   J. Immunol. 185 (7), 3788-3799 (2010)
   PUBMED   20858890
  REMARK    GeneRIF: CD28 costimulation of T-cells was found to augmen
+t the
            expression of Bcl-x substantially
REFERENCE   5  (residues 1 to 233)
  AUTHORS   Wincewicz,A., Baltaziak,M., Kanczuga-Koda,L., Koda,M., Sul
+kowska,U.
            and Sulkowski,S.
  TITLE     GLUT1 and Bcl-xL in relation to erythropoietin in human co
+lorectal
            adenocarcinomas
  JOURNAL   Hepatogastroenterology 57 (101), 741-745 (2010)
   PUBMED   21033220
  REMARK    GeneRIF: Bcl-xl expression(along with GLUT1 and EPO)plays 
+a role in
            promoting self survival of malignant cells under hypoxic c
+onditions
            of colorectal cancer.
REFERENCE   6  (residues 1 to 233)
  AUTHORS   Broome,H.E., Dargan,C.M., Krajewski,S. and Reed,J.C.
  TITLE     Expression of Bcl-2, Bcl-x, and Bax after T cell activatio
+n and
            IL-2 withdrawal
  JOURNAL   J. Immunol. 155 (5), 2311-2317 (1995)
   PUBMED   7650367
REFERENCE   7  (residues 1 to 233)
  AUTHORS   Sedlak,T.W., Oltvai,Z.N., Yang,E., Wang,K., Boise,L.H.,
            Thompson,C.B. and Korsmeyer,S.J.
  TITLE     Multiple Bcl-2 family members demonstrate selective dimeri
+zations
            with Bax
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7834-7838 (1995)
   PUBMED   7644501
REFERENCE   8  (residues 1 to 233)
  AUTHORS   Jaattela,M., Benedict,M., Tewari,M., Shayman,J.A. and Dixi
+t,V.M.
  TITLE     Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and
            activation of phospholipase A2 in breast carcinoma cells
  JOURNAL   Oncogene 10 (12), 2297-2305 (1995)
   PUBMED   7540278
REFERENCE   9  (residues 1 to 233)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displac
+es Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
REFERENCE   10 (residues 1 to 233)
  AUTHORS   Boise,L.H., Gonzalez-Garcia,M., Postema,C.E., Ding,L., Lin
+dsten,T.,
            Turka,L.A., Mao,X., Nunez,G. and Thompson,C.B.
  TITLE     bcl-x, a bcl-2-related gene that functions as a dominant r
+egulator
            of apoptotic cell death
  JOURNAL   Cell 74 (4), 597-608 (1993)
   PUBMED   8358789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staf
+f. The
            reference sequence was derived from BC019307.1.
            
            Summary: The protein encoded by this gene belongs to the B
+CL-2
            protein family. BCL-2 family members form hetero- or homod
+imers and
            act as anti- or pro-apoptotic regulators that are involved
+ in a
            wide variety of cellular activities. The proteins encoded 
+by this
            gene are located at the outer mitochondrial membrane, and 
+have been
            shown to regulate outer mitochondrial membrane channel (VD
+AC)
            opening. VDAC regulates mitochondrial membrane potential, 
+and thus
            controls the production of reactive oxygen species and rel
+ease of
            cytochrome C by mitochondria, both of which are the potent
+ inducers
            of cell apoptosis. Two alternatively spliced transcript va
+riants,
            which encode distinct isoforms, have been reported. The lo
+nger
            isoform acts as an apoptotic inhibitor and the shorter for
+m acts as
            an apoptotic activator. [provided by RefSeq].
            
            Transcript Variant: This variant (1) is also known as bcl-
+xL. It
            encodes a longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of
+ the
            publications that are available for this gene. Please see 
+the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..233
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     Protein         1..233
                     /product="bcl-2-like protein 1 isoform 1"
                     /note="bcl-2-like protein 1; bcl2-L-1; apoptosis 
+regulator
                     Bcl-X"
                     /calculated_mol_wt=25918
     Region          4..24
                     /region_name="BH4"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q078
+17.1)"
     Site            61..62
                     /site_type="cleavage"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="Cleavage, by caspase-1; propagated from
                     UniProtKB/Swiss-Prot (Q07817.1)"
     Region          86..100
                     /region_name="BH3"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q078
+17.1)"
     Region          129..148
                     /region_name="BH1"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q078
+17.1)"
     Region          180..195
                     /region_name="BH2"
                     /experiment="experimental evidence, no additional
+ details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q078
+17.1)"
     Site            210..226
                     /site_type="transmembrane region"
                     /inference="non-experimental evidence, no additio
+nal
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q078
+17.1)"
     CDS             1..233
                     /gene="BCL2L1"
                     /gene_synonym="Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; B
+CL2L;
                     BCLX; BCLXL; BCLXS; DKFZp781P2092"
                     /coded_by="NM_138578.1:367..1068"
                     /note="isoform 1 is encoded by transcript variant
+ 1"
                     /db_xref="CCDS:CCDS13189.1"
                     /db_xref="GeneID:598"
                     /db_xref="HGNC:992"
                     /db_xref="HPRD:02497"
                     /db_xref="MIM:600039"
ORIGIN      
        1 msqsnrelvv dflsyklsqk gyswsqfsdv eenrteapeg tesemetpsa ingnp
+swhla
       61 dspavngatg hsssldarev ipmaavkqal reagdefelr yrrafsdlts qlhit
+pgtay
      121 qsfeqvvnel frdgvnwgri vaffsfggal cvesvdkemq vlvsriaawm atyln
+dhlep
      181 wiqenggwdt fvelygnnaa aesrkgqerf nrwfltgmtv agvvllgslf srk
//
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