Duh, so the question wasn't about getting at the desktop ... 
GetFocus( GetForegroundWindow() )

[download]
works for me, but, Wx will give you hwnd if you use $window->GetHandle(). On a related note, see How to Retrieve another Process' Window Title?

In reply to Re^2: Win32::GuiTest Get Window Focus by Anonymous Monk
in thread Win32::GuiTest Get Window Focus by PyrexKidd

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