Thank you. That solved the issue. Following is the code i am using.
my $data = '#define MANUFACTURER "xyz"';
my $replace = '#define MANUFACTURER(\s+)"xyz"';
my $replace_with = '#define MANUFACTURER$1"abcd"';
my $tmp_str = '$data =~ s/$replace/'.$replace_with.'/g';
eval $tmp_str;
print "\n",$data;
Note: The code takes the same approach as kennethk suggested, except that i didn't want the extra qoutes (and escaping of quotes) in $replace_with variable.
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