You mean like this? This doesn't seem to work either: 
use 5.014000;
use Config::General;

my $conf = new Config::General({replace => 'Z\l$1Z'});

my $string = q/ABC/;
my $search = qr/^(A)/;
say $conf->{config}{replace};
my $replace = '"'. q/$conf->{config}{replace}/ .'"';
$string =~ s/$search/$replace/gee;
say $string;

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I know your solution works when you directly give the replacement inline but not if the replacement itself is in a variable. Perhaps you could comment on how to do this in the above code?

In reply to Re^10: Interpolate into replacement with s//? by philkime
in thread Interpolate into replacement with s//? by philkime

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