Have you worked through the steps in WWW::Mechanize::Firefox::Troubleshooting? Especially the "Installation" section seems particularly applicable to your situation.

In reply to Re: Perl Mechanize runs into error: couldn t connect to localhost - port 4242 [so i never have this strange error] by Corion
in thread Perl Mechanize runs into error: couldn t connect to localhost - port 4242 [so i never have this strange error] by Perlbeginner1

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