Use one of Regexp::Assemble/Regexp::Trie/Regex::PreSuf to assemble an efficient regex then make a single substitution pass 

my %Replacement = {
   q/"-/ => q/"Ä/,
...
);
...
while ...
    s/($rere)/$Replacement{$1}/g;
...

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In reply to Re: script optimization by Anonymous Monk
in thread script optimization by tannx

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