Runs fine for me with 5 million characters on each string - only takes like 3 seconds and this is a really old comp.
use strict;
use warnings;
my ($s1, $s2, $l, $i, $c1, $c2, @m);
$s1 = 'ATACCGGC'; $s1 .= 'ATTTT'x1000000;
$s2 = 'ATTCCGGG'; $s2 .= 'ATTTT'x1000000;
for $i (0..(length($s1)-1)) {
$c1 = substr($s1, $i, 1);
$c2 = substr($s2, $i, 1);
push @m, [$i, $c1, $c2]
if $c1 ne $c2;
}
print (($#m+1) . ' mismatches with target at position(s) ' . join(', '
+, map { $_->[0] } @m) . ' (' . join(', ', map { $_->[2].'->'.$_->[1]
+} @m) . ')');
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