Dear monks, I wrote a script that loops through a reference file that have potentially a specific keyword on each lines. I have a list of these keywords and each time I have a match, I want to print the line of the reference file to a unique txt output file. 
my $ref_db = FastaDb->new($fasta);
while( my $seq = $ref_db->next_seq() ) {
    foreach(@ko_array){
        if($seq->header() =~ m/($_)/){
            open(OUT, ">>".$outdir.$_.".fasta");
            print OUT $seq->header()."\n".$seq->seq()."\n";
            close(OUT);
        }
    }
}

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What I'd like to do is to avoid opening fh each time I have a hit, but rather open them all before the while loop.

In reply to Write to multiple files by julio_514

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