You might want to consider loading the whole thing into a database if it's that large and you need to do a lot of key lookup (e.g. to avoid dupes) as you process the data, particularly if you need to sort on it in different ways or pull out subsets based on certain conditions.

In reply to Re^3: Select only desired features from a text by bitingduck
in thread Select only desired features from a text by remluvr

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