Yes, there is :)
For example: 
open(INPUT, '<', 'Path/file_with_updates.sql') or die ("Error opening 
+file with updates: " . $!);
while (<INPUT>) {
    $dbh->do($_) or die("Error executing query [$_]: " . $dbh->errstr)
+;
}
close(INPUT);

[download]
Do note that this is a rather blatant security risk, since you're executing whatever's in those files directly in the database, but that's your choice. Since SET-commands retain their value during the session, it's safe to just call $dbh->do on each retrieved line.
However, a better way would be to generate the queries in your perl script and use placeholders. For example: 
my $sth = $dbh->prepare('UPDATE Games SET Away_Team_ID=(SELECT Team_ID
+ FROM Teams WHERE Name = ?) WHERE Date = ?') or die("Error preparing 
+statement: " . $dbh->errstr);
open(INPUT, '<', 'Path/file_with_data') or die ("Error opening file wi
+th updates: " . $!);
while (<INPUT>) {
    my ($teamname,$gamedate) = split(',');
    $sth->execute($teamname, $gamedate) or die("Error executing update
+: " . $dbh->errstr);
}
close(INPUT);

[download]
This assumes an inputfile which consists (on each line) of a team name, followed by a comma, and then a date in a format that your used database can grok.

In reply to Re: Followup on executing multiple mysql commands in one call by Neighbour
in thread Followup on executing multiple mysql commands in one call by membender

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