I hate to be there bearer of bad tidings here, but if you'd ever tried using Tie::File on a 34GB file, you'd never be suggesting it to others. It would take weeks to complete.

With the rise and rise of 'Social' network sites: 'Computers are making people easier to use everyday'
Examine what is said, not who speaks -- Silence betokens consent -- Love the truth but pardon error.
"Science is about questioning the status quo. Questioning authority".
In the absence of evidence, opinion is indistinguishable from prejudice.

The start of some sanity?

In reply to Re^2: Deconvolutinng FastQ files by BrowserUk
in thread Deconvolutinng FastQ files by snakebites

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