Don't read the whole file into memory. Read it line by line instead: 

while (<FILE>) {
 ...
 # $_ is the current line
}

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(see Range operators).

Also, there is no need in the @t array: just slice the array returned by split: 

if ((split "\t",$_)[7] =~ /^(?:HIGH|LOW|LRR)$/)

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Also, your condition ($t[7] =~ /HIGH/ && /LOW/ && /LRR/) will never be true as long as one line never contains "HIGH", "LOW" and "LRR" at the same time.

Sorry if my advice was wrong.

In reply to Re: print to match multiple pattern by aitap
in thread print to match multiple pattern by vis1982

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