If you are developing Perl-scripts on Windows or Linux, I'd say have a look at Activestate's Komodo. It is a full featured editor for all kinds of languages (including HTML, PHP, Python, Tcl, and XSLT and limited support for lots of other languages), it integrates the Perl-debugger and can even debug on a remote machine (or so they say, I haven't tried that yet). It has a nice Regex-debugger too and a good GUI for ppm.

Whatever you do, don't try try the free 21 days evaluation license: you will be hooked as soon as you start using it!