For simplicity sake, you can list a compound "and-ed" condition as a series of null assertions:

/
  ^ # anchor so as not to try this at every spot
  (?= chars ) # stars with chars
  (?= .*? this ) # contains this
  (?! .*? that ) # does not contain that
  (?! .* whatever $ ) # does not end in whatever
/xs
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update: edited to include additional whitespace for readability