Check out the CPAN module String::Combination, which will do exactly what you want.

#!/usr/bin/perl
use strict;
use warnings;
use String::Combination qw(combination);

open DICT, 'english-words.txt' or die "Can't open dictionary: $!";
my @dict = <DICT>;
chomp @dict;
my %dict = map { (lc($_) => 1) } @dict;

print "Letters? ";
my $letters = lc <STDIN>;
chomp $letters;

my @results;
for (my $i = 2; $i <= length $letters; $i++) {
    push @results, grep { $dict{$_} } combination $letters, $i;
}

print "@results";
__END__
Output:
Letters? tar
at art rat tar
[download]

Here is an algorithm - certainly not the best - that would work: If you could load your dictionary into memory:

  my @words = <DICTIONARY>;
[download]

  #! /usr/bin/perl -w
  use strict;

  my $input = 'art';

  # Read words from a file instead.
  my @words = ('tar', 'rat', 'fake', 'at', 'unknown');

  my $regex = qr{[$input]+};
  my @matches = grep /^$regex$/, @words;
  print "$_\n" for @matches;
[download]

use strict;
use warnings;

my %words = map { $_ => countLetters($_)} qw/tar rat at attitude tap o
+ther/;

my $input = 'art';
my $input_letters = countLetters($input);

my @matched_words;
WORD: for my $word (sort keys %words) {
    for my $letter (keys %{$words{$word}}) {
        next WORD unless exists($input_letters->{$letter}) && $input_l
+etters->{$letter} >= $words{$word}{$letter};
    }
    push @matched_words, $word;
}

print "Matched words: @matched_words\n";

sub countLetters {
    my $word = shift;
    my %letters;
    $letters{$_}++ for split //, $word;
    return \%letters;
}
[download]

sub nextPermute(\@)
{
    my( $vals )= @_;
    my $last= $#{$vals};
    return ""   if  $last < 1;
    # Find last item not in reverse-sorted order:
    my $i= $last-1;
    $i--   while  0 <= $i  &&  $vals->[$i] ge $vals->[$i+1];
    # If complete reverse sort, we are done!
    return ""   if  -1 == $i;
    # Re-sort the reversely-sorted tail of the list:
    @{$vals}[$i+1..$last]= reverse @{$vals}[$i+1..$last]
      if  $vals->[$i+1] gt $vals->[$last];
    # Find next item that will make us "greater":
    my $j= $i+1;
    $j++  while  $vals->[$i] ge $vals->[$j];
    # Swap:
    @{$vals}[$i,$j]= @{$vals}[$j,$i];
    return 1;
}

@A= sort qw[a r t];
do {
    print @A, "\n";
} while( nextPermute(@A) );
__OUTPUT__
art
atr
rat
rta
tar
tra
[download]

my %anagrams;
while (defined( my $dict_word = <> ) )
{
  my $sorted = sort split //, $dict_word;
  push @{$anagrams{$sorted}} = $dict_word;
}
[download]

Next, since you want words that are a subset of the given char set, you'll have to run through the combinations of the char set, and check if there's a key that matches, giving you an array of words for each match. I leave that as an exercise for OMAR.

#!/usr/bin/perl

# authored by Josh Goldberg <josh@3io.com>
# Jan 10, 2004
#
# ARGV[0] is a string of letters, ARGV[1] is a dictionary file.
# the script searches the dictionary for all combinations/permutations
# of the ARGV[0] that have at least three characters and no character 
+is 
# repeated.  
# Originally authored for use with the widgetWords konfabulator widget
+.

use Algorithm::Permute;
$|=1;

$resultstoprint = 7;
$defaultDictionary = "joshWordList.txt";
@tilePoints = ( 100,300,300,200,100,400,200,400,100,800,500,100,300,10
+0,100,300,1000,100,100,100,100,400,400,800,400,1000 );
$vowels = ( 65,69,73,79,85,89 );
$common = ( 84,78,83,72,82,68,76 );

sub combinations {
    my @list= @_;
    my @pick= (0) x @list;
    return sub {
        my $i= 0;
        while( 1 < ++$pick[$i] ) {
            $pick[$i]= 0;
            return if $#pick < ++$i;
        }
        return @list[ grep $pick[$_], 0..$#pick ];
    };
}

$file = $ARGV[1] || $defaultDictionary;
die "missing dictionary" unless -e $file;
@letters = split //,lc $ARGV[0];

# permute all combinations of 3-8 letters
$combinations = combinations(@letters);
while (@comb = $combinations->() ) {
    next unless scalar @comb > 2;
    $p = new Algorithm::Permute(\@comb);
    while (@res = $p->next) {
        local $"='';
        $wordlist{"@res"} = 1;
    }
}

open LIST, "<$file";
while (<LIST>) {
    chomp;
    $dict{$_} = 1;
}
foreach $word (keys %wordlist) {
    if (exists $dict{$word}) {
        push @matches, $word;
        @res = split //,$word;
        $score = 0;
        for (@res) {
            $score += $tilePoints[ord(uc $_)-65];
        }
        $len = scalar @res;
        $score += $len * 50;
        $score += 400 if $len == 8;
        $wordlist{$word} = $score;
    }
}
close LIST;

print "top Eight Words:\n";
@sorted = reverse sort {$wordlist{$a} <=> $wordlist{$b} } @matches;
for (@sorted) {
    if ($resultstoprint > 0) {
        last if $top++ > $resultstoprint;
    }
    @res = split //,$_;
    print "$_: $wordlist{$_} points\n";
}
exit 0;
[download]

#!/usr/local/bin/perl

use strict vars;
my ($w, $size, $entry, $eval, $cont, $line, $word);
my (@combs, @word);
my (%anagrams, %bysize, %combs);

#read dictionary file
my $file = shift;
open(FILE, "$file") or die "cannot open file $file: $!\n";
print "reading dictionary...\n";
push( @{ $anagrams{join("", sort( split(//,$w) ) )} }, $w ) while( cho
+mp($w = <FILE>) );
close(FILE);

print "enter word and size(q to quit) ";
chomp($cont = <STDIN>);

while($cont !~ m/^q$/i) {

    %combs = @combs = %bysize = ();
    ($word, $size) = split(" ", $cont);
    if($size =~ m/^\d$/) {
        $eval = '$combs{$entry} = 1 if ($entry =~ m/^\w{' . $size . '}
+$/ )';
    } elsif($size =~ m/-/) {
        my ($fnum, $snum) = $size =~ m/(\d+)\s*-\s*(\d+)/;
        $eval = '$combs{$entry} = 1 if ($entry =~ m/^\w{' . $fnum . ',
+' . $snum . '}$/)';
    } elsif($size ne "") {
        $eval = '$combs{$entry} = 1 if length($entry)' . " $size";
    }
    #find all combinations in word
    @word = split(//, $word);
    foreach (&combinations(@word)) {
        $entry = join("", sort(@$_));
        if($size eq "") {
            $combs{$entry} = 1 if length($entry) > 0;
        } else {
            eval $eval;
        }
    }
    @combs = sort(keys %combs);
    # store each word in bysize hash arranged by size
    foreach (@combs) {
        push( @{ $bysize{ length($_) } }, @{ $anagrams{$_} } ) if @{ $
+anagrams{$_} };
    }

    # print words
    &print_set();

    print "enter word and size(q to quit) ";
    chomp($cont = <STDIN>);
}

sub print_set() {
    my ($key, $count, $total);
    my @words;
    foreach $key ( sort { $a <=> $b } keys %bysize ) {
        @words = sort( @{ $bysize{$key} } );
        print "\nwords of size $key:\n";
        $count = 0;
        foreach (@words) {
            $count++;
            print "$_ ";
            print "\n" if $count % 7 == 0;
        }
        $total += $count;
        print "\n";
    }
    print "\ntotal words: $total\n";
    print "\n\n";
}

sub combinations() {
    return [] unless @_;
    my $first = shift;
    my @rest = combinations(@_);
    return @rest, map { [$first, @$_] } @rest;
}

exit;
[download]

D:\PerlProjects\anagram>anagram.pl enable.txt
reading dictionary...
enter word and size(q to quit) perlmonks 3-5

words of size 3:
elk elm els ems ens eon ern
ers ken kep kop kor kos lek
lop mel men mol mon mop mor
mos nom nor nos oes oke ole
oms one ons ope ops ore ors
ose pen per pes pol pom pro
rem rep res roe rom sel sen
ser sol son sop

words of size 4:
elks elms enol eons epos erns eros
kelp kemp keno kens keps kern knop
koel kops kore kors leks leno lens
lone lope lops lore lorn lose mels
meno merk merl moke mole mols monk
mons mope mops more morn mors mosk
noel noes nome noms nope norm nose
okes oles omen omer ones open opes
ores orle pens peon perk perm peso
poem poke pole pols pome poms pone
pons pore pork porn pose prom pros
rems repo reps roes role romp roms
rope rose skep sloe slop soke sole
some sone sore sorn

words of size 5:
enols enorm enrol kelps kemps kenos kerns
knops knosp koels krone lemon lenos loner
loper lopes lores loser melon merks merls
meson mokes moles monks moper mopes morel
mores morns morse nerol noels nomes norms
omens omers opens orles pelon peons perks
perms plonk poems poker pokes poler poles
pomes pones pores porks porns poser proem
prole proms prone prose repos roles romps
ropes senor skelm skelp slope smerk smoke
snore sorel sperm spoke spore

total words: 223


enter word and size(q to quit) q
[download]