Are you asking for SQL statement advice, or the perl code to access them?

SQL: "update {TABLENAME} set {FIELDNAME}={NEW VALUE} where {CONDITIONS}"

Perl: read up on DBI and the DBD modules for your database.

Update: Just noticed that you have more than one entry in your addresses field. Bad practice, it limits you. You should have multiple records:

DESPAIR	Iamhere@place.org
DESPAIR	andheretoo@nother.place.org