To be a little more clear on this, the basic @INC list is compiled in to /usr/bin/perl or libperl.a or whatever. There isn't a file to edit as far as I know.

As others mentioned, you need to recompile to remove items from the list and I know of no way to add them "globally" without doing the same.

Actually, I've no idea how to knock one out at compile time either... I'm no help at all =(

--
$you = new YOU;
honk() if $you->love(perl)