I work sitting at either a WinXP or macOSX box.
I use the Eclipse 3.0 IDE with the epic perl plugin on both platforms. It provides continuous syntax checking via my installed perl executable.
On WinXP I use ActivePerl. On the mac I compiled my own perl (if I remember correctly, the preinstalled one had debugging on, so DBI couldn't be installed)
I have apache and MySQL installed on both machines so that I can test my development locally.
My websites run on both solaris and x86 linux machines requiring no code changes at all.
I do often ssh into the solaris box so I can do easier command line file manipulations, but I intend to look at the perl power tools soon to see if I can make that redundant.