If you want the Windows Drive Serial number, the Win32API::File package can do what you want. I'm not sure if it's current or deprecated.

Try

use Win32API::File qw (:Func );

my ( $sRootPath, $osVolName, $lVolName, $ouSerialNum, $ouMaxNameLen, $
+ouFsFlags, $osFsType, $lFsType );

$sRootPath = "C:/";

GetVolumeInformation( $sRootPath, $osVolName, $lVolName, $ouSerialNum,
+ $ouMaxNameLen, $ouFsFlags, $osFsType, $lFsType );

#----
print "\nRoot:\t$sRootPath\n";
print "VolName:\t$osVolName\n";
print "SerialNumber:\t$ouSerialNum\n";
printf "Hex SerialNumber:\t%x\n", $ouSerialNum;
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For me, this returns

Root:   C:/
VolName:        mecano
SerialNumber:   2226596281
Hex SerialNumber:       84b729b9
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the stardard 'vol c:' (which you could backtick) returns

 >vol c:
 Volume in drive C is mecano
 Volume Serial Number is 84B7-29B9
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-jim

Update: forgot the 'use' line in the code snippet