The problem of maintaining and questioning a database is distinct from that of producing a GUI for the user. The two are best given seperate solutions with a bit of interface code to match them up.

DBI is the module you want for talking to databases. It is the common interface to a whole family of specific database drivers in the DBD namespace. There are lots of helper modules for various purposes which the DBI search should turn up.

For the GUI, it depends on what you want. For CGI, there is CGI.pm, which comes with Perl. For a desktop on a local machine, Tk is platform agnostic and in common use.

Some assembly required.