You will be in for more hurt than is worth the effort I fear. The File::Spec module splits the path (on Win32) on \x5C. I think you will need to recompile your Perl in a way that it uses forward slashes in all its configuration parameters, and you will need to patch at least File::Spec. I've recently learned that CPANPLUS also does not use File::Spec, and I assume that there are other modules that don't use it, but still perform path manipulation, so you will possibly need to patch these as well; maybe you are lucky though and the modules performing path manipulation are unix-centric and thus think that the forward slash is the measure of all things and spaces in filenames are forbidden.

A smallish hack might be to edit the main Config.pm of Perl and change all paths there, but I think you need to patch the Perl.exe binary as well and "fix" all paths there too.