In order to run a Tk gui in windows, youll first need to install a Tk distribution for Win32.
Searching google (it is a good idea to google prior to question), ive found
TCL/Tk on Windows FAQ.
Install it, and take a look at ported Perl distributions, as well as modules needed.
ActiveState may have this things already prepared, but i dont really know it (i dont use windows).
The other question: AFS, as a network distributed file system, can be mounted from anyware, under windows youll need (googled again)
AFS for Win.