For projects I was considering, Maypole commits too much to a particular strategy. I've found frameworks like that to be very great to get something started, but almost everyone wants to tweak something (especially customers, and at random times, and always urgent), and Maypole didn't look like it could "slide laterally" very well.

That's actually why I wrote CGI::Prototype - to try to get the framework out of the way, yet have a nice framework where I'd have a place to write each thing once.