If you are already familiar with DBI then you should use it for this.

If you are already familiar with Sybase's OpenClient API (in C), then sybperl (or, more precisely, the Sybase::CTlib module) may be a reasonable choice.

You can also look at Sybase::Simple which provides a few very simple calls on top of Sybase::CTlib.

You may also be interested in this node.

Michael