The best time to move to Perl 6 is after everyone else has already done so

By that argument nobody ever moves to Perl 6.

The vast majority of programming jobs don't require anything more advanced than 5.x

The vast majority of programming jobs don't require anything more advanced than assembler. The question is will Perl 6 make the majority of programming jobs easier than Perl 5.

I think it will. I certainly hope it will since I'm already abandoning Perl 5 for other languages like Ruby which make my life easier - but I still have a great fondness for Perl and am looking forward to its new incarnation.