I have been using AS Perl for about three years now in a business environment, mainly for Apache/mod_perl dynamic website scripting, but also for scripts to parse insurance statistics in different file-formats into a format for loading in our database. I use Komodo as editor and it ties in nicely with AS Perl.

PPM is a great utility to get compiled modules without compiling them yourself and althouhg not all of the CPAN modules are available, many are and the most important missing modules are compiled by third parties (such as PodMaster) and made available on their PPM-sites.