In theory, yes; in practice, no.

Reading/writing from/to RAM is many times faster and reorganizing the storage in RAM is much easier.

In order to get any kind of acceptable speed out of your HD, lots of tables need to be updated and saved to allow fast access to the data.

In RAM-storage, in a pinch you can simply walk through your RAM to find the data you need, if you do that on a HD, you can go out and get yourself a coffee (and a donut or a toasted bagel) and return before your data is found.