I don't know much about autouse, as I haven't tried it out. It looks like autouse's purpose is more context-oriented while SelfLoader is useful in a broader context. The benefit of delaying a 'use Module' command is a side-effect of SelfLoader, while it seems to be the main purpose of autouse.

SelfLoader delays the compilation of methods/subroutines until they are called, while autouse delays the execution of 'using' a module until it is explicitly called.