Just keep in mind that certain constructs, such as < > do not accept lexical handles unless they are in "simple" variables. E.g.

while ( <$handles[ 3 ]> ) {
  # do something with last line read
}
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won't work. You need to do something like this:

while ( defined( my $line = $handles[ 3 ]->getline ) ) {
  # do something with $line
}
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or

frobnicate( $handles[ 3 ]->getline ) until $handles[ 3 ]->eof;
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or, if you really prefer to avoid invoking methods on then handle, the you can do this

my $tmp = $handles[ 3 ];
while ( <$tmp> ) {
  # go crazy
}
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