When used as a tied file handle:

• I think you have no choice but to use a typeglob if you want a tied file handle.

As of 5.8.0, filehandle ties are attached to the IO handle, not the typeglob, so you can tie even globless lexical filehandles:

use Tie::Handle;
use Symbol "geniosym";
my $fh = geniosym;
tie *$fh, "Tie::StdHandle" or die;
print tied(*$fh);
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The * is required only to let tie/tied know you want a filehandle tie, not a scalar tie; no actual typeglobs are used, except temporarily.