No local MySQL but with DBI and SQLite this works:

#!/usr/bin/perl -w
use strict;
use DBI;
use MIME::Base64;
my $dbh = DBI->connect('DBI:SQLite:dbname=test_blob.db', '', '');

$dbh->do('CREATE TABLE test_blob( a text , b text , Bindata BLOB )');

my $bindata = "ABC" . qq|\x00| . "DEF";
#added
$bindata = encode_base64($bindata);

my $sth1 = $dbh->prepare('INSERT INTO test_blob VALUES(?,?,?)' );
my @ar = qw|foo doog|;
$sth1->execute(@ar, $bindata);

my $sth2 = $dbh->prepare('SELECT Bindata FROM test_blob');
$sth2->execute();

my $row = $sth2->fetch();
my $fetched_data = $row->[0];

$sth2->finish();
$dbh->disconnect;

print decode_base64($fetched_data);
1;
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And from the database:

.schema test_blob
CREATE TABLE test_blob( a text , b text , Bindata BLOB );
sqlite> select * from test_blob;
foo|doog|QUJDAERFRg==
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That code you posted had all sorts of other problems so I grabbed the above from a previous post. Update: Come to think of it, you could replace that SQL creation code with something like:

perl -e "$lf = @ARGV;$sql= 'insert into BLAH (' . eval{join ',',@ARGV 
+} . ') VALUES (' . eval{join ',', split//,'?' x $lf} . ')'; print $sq
+l;" DOGS CATS FISH ANIMALS TRIKES KITES
insert into BLAH (DOGS,CATS,FISH,ANIMALS,TRIKES,KITES) VALUES (?,?,?,?
+,?,?)
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