I think you first need to see whether you can determine just what's doing the caching. This wouldn't be specifically a Perl issue, though. You might get some hint from the names of the caches, if you know where they live. You may be able to disable them using msconfig.exe ( Start | Run... | msconfig.exe).

AFAIK, there's no Perl module to disable caches (but don't take my word for it - CPAN is full of surprises).