While Perl/Tk may not be "native to Perl", it *is* part of Active State's standard distribution, and runs perfectly fine when you use perlapp.  All that perlapp is doing "behind the scenes" is unbundling the program source code, modules and .dll's necessary for running Perl on a platform where it may not have been formally installed. It's not actually converting the basic program to machine-dependent object code.

I personally favor Perl/Tk since I began learning it at the same time as Perl itself, and, when I started using Perl under Windows, was delighted to find that it works there too.  You may want to give it a try -- it's nice to be able to write Perl for one platform and have it often run seamlessly on another!