I will second the use of mod_perl with Template Toolkit and mysql (powered through DBI of course). I know that there are others out there who would highly suggest postgresql over mysql, but for some reason I've never really looked at postgresql. Perhaps it's because a lot of my past development has been on win32 machines; if I am remembering correctly, they have not always had a version of its software for win32.
In any case, mod_perl coupled with Template Toolkit and either mysql or postgresql I guess. :)
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