ActiveState has the PerlScript plugin, which acts as an IE browser plugin and which enables Internet Explorer to run Perl code where you would otherwise place JavaScript. This is Windows-only though.

Maybe you can tell us the problem you want to solve by using this technique. Usually, it's better to use either server-side techniques like Template Toolkit or HTML::Template or to use JavaScript. JavaScript has native regular expressions that have about the same power as Perls nowadays.