grep(1) -v -f (fgrep -v) does not do what one would hope, and so I whipped up the following:

UPDATE:

• FIXED DOH, -P returns the whole FILE
• FIXED DOH, -P returns more matches (false negatives) than vfgrep without -P (stupid cut & paste error)
• *SIGH* The non-functioning of -v -f is not intended and appears to be a bug that shows up under some circumstances (in this case cygwin with grep 2.5.10 and some large CSVs). Even where the native grep does work this implementation may be faster (plain is about 6x and -P 18x than GNU fgrep -v here)

use Getopt::Std;
use vars qw'$opt_f $opt_P $VERSION';
$VERSION = 0.08;

unless( @ARGV ){
    print<<EOUsage;
usage: vfgrep [-P] -f PATTERNS [FILE]

-P prune patterns on match, if a pattern will only match once per file
   this can speed up execution by discarding the pattern once it has m
+atched.

EOUsage
    exit;
}
getopts('Pf:');

die("vfgrep requires a pattern file\n") unless defined $opt_f;
open(PAT, $opt_f) or die("Error opening pattern file '$opt_f': $!\n");

#Strip any sort of EOL garbage
#Also pre-compile the regexp for a major performance boost
my @PAT = map{ y/\r\n//d; qr/$_/ } <PAT>;
close(PAT);

if( $opt_P ){
    REC: while(<>){
    #Premature optimization?
    last unless scalar @PAT;

    foreach my $i (0 .. $#PAT ){
        splice(@PAT, $i, 1) && next REC if /$PAT[$i]/;
    }
    print;
    }
    print <> unless eof; #Pairs with last unless
}
else{
  REC: while(<>){
      foreach my $pattern ( @PAT ){
      next REC if /$pattern/;
      }
      print;
  }
}
__END__
Todo: mmap?
[download]

Thanks to tye, Corion and diotalevi for algorithm assistance in pruning a list currently being iterated over.

Note: In my tests case (what I wrote this for) pruning cut the run time by 2/3.