The warnings you're getting aren't anything to be worried about in production. What I believe is happening is that when Apache2::Reload is actually reloading your code it has to redefine the subroutines, which causes an informational warning, but because you have warning's set to FATAL it causes your application to die. I would suggest not using FATAL until you are ready to launch and then don't use it in conjunction with Apache2::Reload.