Greetings, hozefa,

Your program seems to run fine, and (I'm assuming) does exactly what you want it to.  So the following are all merely suggestions; as you have already achieved the primary goal of a working program ...

1. On Windows (at least on the systems I've used, ActiveState Perl with Win2000 or XP), it doesn't seem to matter where whether you specify a shebang line; Perl will still execute successfully.  However, your shebang (#!c:perl/perl.exe) may be misleading, as it's unlikely that the executable exists in the Perl top directory (it's more likely in C:\Perl\Bin).
2. I find it easier to read a program with proper indentation.  It's up to you whether you use:

   if ($sign==5) {
       print "the Multiplication Table For $num1 and $num2 is \n";
   
       for (1 ..$num2) {    
           print "$_ X $num1 = ", $_ * $num1, "\n";        
       }
   }
   [download]

   (which I like) or:

   if ($sign==5)
       {
           print "the Multiplication Table For $num1 and $num2 is \n";
   
           for (1 ..$num2) {    
               print "$_ X $num1 = ", $_ * $num1, "\n";        
           }
       }
   [download]

   but I think they are both preferrable to:

   if ($sign==5)
           {
   print "the Multiplication Table For $num1 and $num2 is \n";
   
   for (1 ..$num2)
       {    
   print "$_ X $num1 = ", $_*$num1, "\n";        
       }
           }
   [download]

   which is misleading and erratic.
3. When doing == comparisons, a nice trick is to put the constant on the left.  (This is completely an optional suggestion; I would never fault a program for not doing it). I find it helpful because if you ever mistype "==" as "=", then the compiler will catch the error, as you can't assign something to a constant (if (1=$sign) { ... }).
4. Check your program for spelling (eg. "Mulitiplication"), and consider better variable names (eg. "$sign" might be better labelled "$operation").
5. You might want to use if ... elsif ... instead of individual "if" statements.  They don't change the functionality, but do allow some conditionals not to be evaluated (not necessarily a slow down in a small program, but a good practice nonetheless), and with a tighter grouping, may make the program easier to read:

   if (1 == $sign) {
       print "The Sum of the Numbers $num1 + $num2 is ", $num1 + $num2, "
   +\n";
   } elif (2 == $sign) {
       print "The Difference of the numbers $num1 - $num2 is ",$num1 - $n
   +um2, "\n";
   } elsif (3 == $sign) {
       print "The Product of $num1 X $num2 is ",$num1 * $num2 , "\n";
   } elsif (4 == $sign) {
       print "The Division of $num1 / $num2 is ", $num1 / $num2 , "\n";
   } elsif (5 == $sign) {
       print "the Multiplication Table For $num1 and $num2 is \n";
       for (1 ..$num2) {    
           print "$_ X $num1 = ", $_ * $num1, "\n";        
       }
   }
   [download]

Good luck in all your programming tasks.  May you enjoy programming in Perl as much as many of us have!