I use the Perl-Blue theme on 1024*768 and did not notice anything wrong except very occasionally the main node part of the screen pushing the nodelets away if there was a very long unbreakable text in the main part.
CountZero
"If you have four groups working on a compiler, you'll get a 4-pass compiler." - Conway's Law
Comment on Re: Perl Monks with Perl-Blue theme on a 1024x768 Display