No.

Spiffy is a source filter, Moose is not.

Spiffy is a class builder, Moose is complete object system, including a complete underlying meta system.

Spiffy is written by Ingy, Moose is not ;)

Spiffy is a only sort of based on Perl 6, Moose is heavily based on Perl 6 and will be meta-level compatible with Perl 6 (which should make Ponie's job much easier).

There are a number of other differences, but they get into deep and heavy details, which I won't bother dumping here.