i want to take the line if it not starts with INFO/DEBUG/ID/<blankspace>.

Here is one way to do it.

while(<DATA>){
if(($_ !~ /^(INFO|DEBUG|ID|\s+)/)){
      print"Line check\n";
}
}

outputs:
--------
Line check
Line check

__DATA__
ID      Run     Timestamp       Entry   Attempt Message Type    Messag
+e

13      251     2006-07-06 13:21:14.0   1       1       INFO    Starti
+ng for (ActivityId=13, DataSource=dunkle-rs)
13      251     2006-07-06 13:21:14.0   2       1       INFO    Queryi
+ng remote datasource ...
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