You may need a product such as TVicPort to get direct access to the hardwar IO ports, if the package included in the hardware down't already have a dll to do this. (In either case, you have to set up access from perl to the DLL.)

Direct access to the serial IO ports is specially allowed in Win32. Access to the other IO addresses is generally restriced. Maybe another monk knows of a module to get around this and go direct to the hardware.