My suggestion would be to learn something about a content manager ( we have used Bricolage on a largish site that is yet to be launched ) and then decide how you want to approach the site structure. You will find you have a mass of options and it is best to understand them first, before you try to re-design the site.

I also have a small team working on a site using Krang as a prototype for a client who is looking at magazine sites. It is specifically magazine oriented so it may not suit you but it is rather robust and well featured also.

jdtoronto