No you can't use wildcards in the directory name, but you can use glob to get all matching directory names. Something like this:

foreach my $dir (grep -d, glob "/apps/inst2/metrica/ON-SITE/backup/sch
+ema/*.tdef") {
    print "Opening directory $dir\n";
    opendir(OLD, $dir) or die "Can't open directory $dir: $!";
    while(my $file = readdir OLD) {
        next if $file eq '.' or $file eq '..';
        print "  File: $file\n" if -f $file;
        print "   Dir: $file\n" if -d $file;
        print "  Link: $file\n" if -l $file;
    }
    closedir OLD;
}
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