I can only give you general guidance, because I'm not well versed in the workings of mysql servers, but it sounds like a good bet that you can setup multiple socket connections in threads. I would first look at the POE Cookbook, it probably has a ready made example.

Otherwise you have a couple of possibilties. IO::Select and threaded. IO::Select will let you add socket filehandles then loop thru them and read them as they reply. The drawback is a huge transfer from one server, will block the others until it is finished.

An alternative, would be to have your main thread connect to the mysql server, then have it pass the socket filehandles off to a separate thread for reading. That way they won't block each other. See FileHandles and threads