I use ConTEXT in WinXP. Superb editor, it's really sped up my productivity. I too tried Komodo and several others, but found them a bit slow.

With ConTEXT you can define macros and set keys F9-F12 to different functions: "run this script", "run perl -c on this script", "run with -d:ptkdb debugger", "profile..".

It also has a function to compare your file with another saved file, and numerous other facilities. Supports many languages, too.