I'm moderately confident the answer is no for Perl (although of course it's impossible to be sure). I can think of a few reasons why this might be - poor threading support, unpleasant embedding system, large memory footprint, etc. An extension language for a game needs to be fast, light on memory use and easy to bind to from your implementation language.

I played with integrating Quake 3 and Perl once upon a time: Coagula. I did get a simple bot up and running around. The performance was terrible, but I never really put much time into it.

-sam