Most people use MiME::Lite to avoid those hassles. I think the preferred way to do it is with a Bcc list, but your ISP may think you are spamming.

#! /usr/bin/perl -w
#
#This program takes a list of email addresses and emails them.
#NOTE: This program must be changed for each edition of the newsletter
#

use strict;
use MIME::Lite;

open(INDEX, "<index.htm") or die "Can't open index.htm file";
my $body = do { local $/; <INDEX> }; #Slurp the whole file in
close(INDEX);

my $msg = MIME::Lite->new(
       Subject =>'New phase of funding to support life-saving vaccines
+',
       Type    =>'multipart/related',
       );
   
$msg->attach(Type =>'text/html', Data =>$body, Disposition=>'inline');
$msg->attach(Type =>'image/jpg', Path =>'index_files/Hivheader1.jpg', 
+Disposition=>'inline');
$msg->attach(Type =>'image/jpg', Path =>'index_files/image001.jpg', Di
+sposition=>'inline');
$msg->attach(Type =>'image/jpg', Path =>'index_files/image002.jpg', Di
+sposition=>'inline');
$msg->attach(Type =>'image/gif', Path =>'index_files/image003.gif', Di
+sposition=>'inline');
$msg->attach(Type =>'image/jpg', Path =>'index_files/image004.jpg', Di
+sposition=>'inline');
$msg->attach(Type =>'image/jpg', Path =>'index_files/image005.jpg', Di
+sposition=>'inline');
$msg->attach(Type =>'image/jpg', Path =>'index_files/image006.jpg', Di
+sposition=>'inline');
   
while (<>) {
   $msg->add(To=>"$_");
   $msg->send("sendmail","/usr/bin/qmail-inject");
}; #while there are more address on the command line
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